Article

Transcriptional regulation of HSCs in Aging and MDS reveals DDIT3 as a Potential Driver of Dyserythropoiesis

2021-09-08

Abstract excerpt

<h4>ABSTRACT</h4> Myelodysplastic syndromes (MDS) are hematopoietic stem cell (HSC) malignancies characterized by ineffective hematopoiesis, with increased incidence in elderly individuals. In this work, we analyzed the transcriptome of human HSCs purified from young and elderly healthy donors, as well as MDS patients, identifying transcriptional alterations following eight different patterns of expression. While...

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Literature Corpus work: 9b4d4c1d-8877-5531-89a2-d31920f2a7ee
DOI: 10.1101/2021.09.08.459384

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