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The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes

9 Dec 2022

Abstract excerpt

Abstract Myelodysplastic syndromes (MDS) are hematopoietic stem cell (HSC) malignancies characterized by ineffective hematopoiesis, with increased incidence in older individuals. Here we analyze the transcriptome of human HSCs purified from young and older healthy adults, as well as MDS patients, identifying transcriptional alterations following different patterns of expression. While aging-associated lesions...

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PMID: 36494342
DOI: 10.1038/s41467-022-35192-7

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