Article

IL-1β–mediated inflammatory signaling drives ineffective erythropoiesis in early-stage myelodysplastic syndromes

2023-09-30

Abstract excerpt

<h4>ABSTRACT</h4> Myelodysplastic syndromes (MDS) are a group of incurable hematopoietic stem cell (HSC) neoplasms characterized by peripheral blood cytopenias and a high risk of progression to acute myeloid leukemia. MDS represent the final stage in a continuum of HSCs’ genetic and functional alterations and are preceded by a premalignant phase, clonal cytopenia of undetermined significance (CCUS). Dissecting th...

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Literature Corpus work: 87f5dada-d8d0-570e-a744-980c82e15e78
DOI: 10.1101/2023.09.28.560018

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