Article

Overweight status drives early tumor microenvironment reprogramming in pancreatic ductal adenocarcinoma: a cell-type-resolved Bayesian hierarchical modeling and interactome analysis

2026-05-17

Abstract excerpt

<h4>ABSTRACT</h4> Obesity significantly increases the risk of pancreatic ductal adenocarcinoma, yet a comprehensive understanding of obesity-driven tumor microenvironment remodeling remains incomplete. We developed a cell-type-resolved transcriptomic model using bulk RNA sequencing data from the Clinical Proteomic Tumor Analysis Consortium cohort (n=140) stratified by body mass index. A custom functional gene sig...

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Literature Corpus work: c260f373-8287-5b0a-8773-ff82cac38699
DOI: 10.64898/2026.05.14.721695

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