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LAMA3 Orchestrates Immune Evasion and Metabolic Reprogramming in Pancreatic Ductal Adenocarcinoma: Insights from Multi-Omics Integration

2025-10-09

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<title>Abstract</title> <p>Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy characterized by immune evasion and metabolic reprogramming. The role of laminin subunit alpha 3 (LAMA3), a key component in adhesion and signaling, remains poorly defined in PDAC. Methods We performed an integrative multi-omics analysis combining bulk and single-cell transcriptomics, WGCNA, CNV inference, pseudot...

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Literature Corpus work
76e8ece2-49d5-5f0e-9686-8db16b291467
DOI
10.21203/rs.3.rs-7635163/v1
Open publication

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