Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Primary and metastatic cellular landscapes in human pancreatic cancer

26 Jun 2025

Abstract excerpt

T cells in metastases, as well as the enrichment of complement pathway encoding genes in immunosuppressive tumor-associated macrophages, consistent with profound immunosuppression in metastatic disease. In cancer-associated fibroblasts, we identified a unique upregulation of metabolic genes, including UPP1, in metastasis. In cancer cells, we uncovered a specific gene signature upregulated in liver metastases;...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Pancreatic and Hepatic Oncology Research
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40703450
DOI: 10.1016/j.isci.2025.113012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Primary and metastatic cellular landscapes in human pancreatic cancerPMID 40703450Read ↗

Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Metabolic reprogramming shapes the immune microenvironment in pancreatic adenocarcinoma: prognostic implications and therapeutic targetsSemantic proximity Read ↗

Multi-omic Characterization of Pancreatic Cancer-Associated Macrophage Polarization Reveals Deregulated Metabolic Programs Driven by the GMCSF-PI3K PathwaySemantic proximity Read ↗

A Novel Perspective on Genes Driving Metastatic Pancreatic Cancer Revealed by Single-cell RNA SequencingSemantic proximity Read ↗

Charting the transcriptomic landscape of primary and metastatic cancers in relation to their origin and target normal tissuesSemantic proximity Read ↗

The dynamic dysregulated network identifies stage-specific markers during lung adenocarcinoma malignant progression and metastasisSemantic proximity Read ↗

Single-cell RNA-seq integration unveils liver vulnerability to tumor metastases: insights from myeloid cell characterization in pancreatic cancer liver metastaticSemantic proximity Read ↗

Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF–PI3K pathwaySemantic proximity Read ↗

Integrative transcriptomics and single-cell analysis uncover prostaglandin-linked communication in high-risk pancreatic cancerSemantic proximity Read ↗

Identifying metabolic reprogramming phenotypes with glycolysis-lipid metabolism discoordination and intercellular communication for lung adenocarcinoma metastasis.Semantic proximity Read ↗

Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets.Semantic proximity Read ↗

Transcriptomic plasticity is a hallmark of metastatic pancreatic cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.