Article
Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity.
Scientific data - 25 Sept 2023
West Clare E, Karim Mohd, Falaguera Maria J, Speidel Leo, Green Charlotte J, Logie Lisa, Schwartzentruber Jeremy, Ochoa David, Lord Janet M, Ferguson Michael A J, Bountra Chas, Wilkinson Graeme F, Vaughan Beverley, Leach Andrew R, Dunham Ian, Marsden Brian D
Abstract excerpt
Advancing age is the greatest risk factor for developing multiple age-related diseases. Therapeutic approaches targeting the underlying pathways of ageing, rather than individual diseases, may be an effective way to treat and prevent age-related morbidity while reducing the burden of polypharmacy. We harness the Open Targets Genetics Portal to perform a systematic analysis of nearly 1,400 genome-wide association...
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