Article

CD4 <sup>+</sup> T cells fuel the Duchenne cardiomyopathy

2025-11-01

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a X-linked genetic disorder, in which cardiomyopathy represents a major cause of mortality. Although myocardial inflammation and fibrosis are hallmarks of the disease, the role of adaptive immunity in cardiac pathology remains poorly defined. Using the Mdx mouse model, we demonstrate that T and B lymphocytes accumulate in the heart and that activation occurs in heart-draining l...

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Literature Corpus work: 9b2ea92c-fdad-510a-84b6-271213f08d88
DOI: 10.1101/2025.10.30.684828

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