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Article

Inflammatory predisposition predicts disease phenotypes in muscular dystrophy

5 Sept 2016

Abstract excerpt

Duchenne muscular dystrophy is an incurable genetic disease that presents with skeletal muscle weakness and chronic inflammation and is associated with early mortality. Indeed, immune cell infiltration into the skeletal muscle is a notable feature of the disease pathophysiology and is strongly associated with disease severity. Interleukin (IL)-10 regulates inflammatory immune responses by reducing both M1...

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PMID: 29259687
DOI: 10.1186/s41232-016-0019-0

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