Article

Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH

2021-09-14

Abstract excerpt

The role of EGFR in lung cancer is well described with numerous activating mutations that result in phosphorylation and tyrosine kinase inhibitors that target EGFR. While the role of the EGFR kinase in non-small cell lung cancer (NSCLC) is appreciated, control of EGFR signaling pathways through dephosphorylation by phosphatases is not as clear. In recent work we identified mutations in Protein Tyrosine Phosphatase...

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Literature Corpus work: 9b060fdd-45cf-5cb6-ba10-faaab8d8c76a
DOI: 10.1101/2021.09.14.460311

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