Article
Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH.
PLoS genetics - 1 Sept 2022
Swiatnicki Matthew R, Rennhack Jonathan P, Ortiz Mylena M O, Hollern Daniel P, Perry Ashlee V, Kubiak Rachel, Riveria Riveria Sarai M, O'Reilly Sandra, Andrechek Eran R
Abstract excerpt
The role of EGFR in lung cancer is well described with numerous activating mutations that result in phosphorylation and tyrosine kinase inhibitors that target EGFR. While the role of the EGFR kinase in non-small cell lung cancer (NSCLC) is appreciated, control of EGFR signaling pathways through dephosphorylation by phosphatases is not as clear. Through whole genome sequencing we have uncovered conserved V483M...
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