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Article

EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity.

Cancer research - 15 May 2007

Vikis Haris, Sato Mitsuo, James Michael, Wang Daolong, Wang Yian, Wang Min, Jia Dongmei, Liu Yan, Bailey-Wilson Joan E, Amos Christopher I, Pinney Susan M, Petersen Gloria M, de Andrade Mariza, Yang Ping, Wiest Jonathan S, Fain Pamela R, Schwartz Ann G, Gazdar Adi, Gaba Colette, Rothschild Henry, Mandal Diptasri, Kupert Elena, Seminara Daniela, Viswanathan Avinash, Govindan Ramaswamy, Minna John, Anderson Marshall W, You Ming

Abstract excerpt

The use of tyrosine kinase inhibitors (TKI) has yielded great success in treatment of lung adenocarcinomas. However, patients who develop resistance to TKI treatment often acquire a somatic resistance mutation (T790M) located in the catalytic cleft of the epidermal growth factor receptor (EGFR) e...

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Identifiers

PMID: 17510392
DOI: 10.1158/0008-5472.CAN-07-0217
PMCID: PMC3460269

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17510392-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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