Article
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Science (New York, N.Y.) - 21 May 2004
Wang Zhenghe, Shen Dong, Parsons D Williams, Bardelli Alberto, Sager Jason, Szabo Steve, Ptak Janine, Silliman Natalie, Peters Brock A, van der Heijden Michiel S, Parmigiani Giovanni, Yan Hai, Wang Tian-Li, Riggins Greg, Powell Steven M, Willson James K V, Markowitz Sanford, Kinzler Kenneth W, Vogelstein Bert, Velculescu Victor E
Abstract excerpt
Tyrosine phosphorylation, regulated by protein tyrosine phosphatases (PTPs) and kinases (PTKs), is important in signaling pathways underlying tumorigenesis. A mutational analysis of the tyrosine phosphatase gene superfamily in human cancers identified 83 somatic mutations in six PTPs (PTPRF, PTPRG, PTPRT, PTPN3, PTPN13, PTPN14), affecting 26% of colorectal cancers and a smaller fraction of lung, breast, and...
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