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Article

Induction of lung adenocarcinoma in transgenic mice expressing activated EGFR driven by the SP-C promoter.

Cancer science - 1 Sept 2008

Ohashi Kadoaki, Rai Kammei, Fujiwara Yoshiro, Osawa Masahiro, Hirano Seiki, Takata Katsuyoshi, Kondo Eisaku, Yoshino Tadashi, Takata Minoru, Tanimoto Mitsune, Kiura Katsuyuki

Abstract excerpt

To investigate the role of an activating epidermal growth factor receptor (EGFR) mutation in lung cancer, we generated transgenic mice expressing the delE748-A752 mutant version of mouse EGFR driven by the SP-C promoter, which is equivalent to the delE746-A750 mutation found in lung cancer patients. Strikingly, the mice invariably developed multifocal lung adenocarcinomas of varying sizes at between 5 and 6 weeks...

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Identifiers

PMID: 18564139
DOI: 10.1111/j.1349-7006.2008.00875.x
PMCID: PMC11158773

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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