Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SHP2E76K mutant promotes lung tumorigenesis in transgenic mice.

Carcinogenesis - 1 Aug 2014

Schneeberger Valentina E, Luetteke Noreen, Ren Yuan, Berns Hartmut, Chen Liwei, Foroutan Parastou, Martinez Gary V, Haura Eric B, Chen Jiandong, Coppola Domenico, Wu Jie

Abstract excerpt

Lung cancer is a major disease carrying heterogeneous molecular lesions and many of them remain to be analyzed functionally in vivo. Gain-of-function (GOF) SHP2 (PTPN11) mutations have been found in various types of human cancer, including lung cancer. However, the role of activating SHP2 mutants in lung cancer has not been established. We generated transgenic mice containing a doxycycline (Dox)-inducible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Adenoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

Share to Cell Transformation, Neoplastic

Share to Immunoprecipitation

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Real-Time Polymerase Chain Reaction

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Open in PubMed Open full text

Identifiers

PMID: 24480804
DOI: 10.1093/carcin/bgu025
PMCID: PMC4123642

Genes

PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SHP2E76K mutant promotes lung tumorigenesis in transgenic mice.PMID 24480804Read ↗

HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.Semantic proximity Read ↗

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.Semantic proximity Read ↗

Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesisSemantic proximity Read ↗

Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model.Semantic proximity Read ↗

Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment.Semantic proximity Read ↗

Induction of lung adenocarcinoma in transgenic mice expressing activated EGFR driven by the SP-C promoter.Semantic proximity Read ↗

Molecular characterization of canine SHP2 mutants and anti-tumour effect of SHP2 inhibitor, SHP099, in a xenograft mouse model of canine histiocytic sarcoma.Semantic proximity Read ↗

Genetic and epigenetic alterations in lung tumors from bitransgenic Ki-rasG12C expressing mice.Semantic proximity Read ↗

A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma.Semantic proximity Read ↗

WBP2 Negatively Regulates Hippo Pathway By Competitively Binding To WWC3 With LATS1 To Promote The Malignant Phenotype Of Non-Small Cell Lung CancerSemantic proximity Read ↗

Phosphorylation of PLCγ1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung CancerSemantic proximity Read ↗

High SHP2 expression determines the efficacy of PD-1/PD-L1 inhibitors in advanced KRAS mutant non-small cell lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.