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Article

Concise review: hematopoietic stem cell aging, life span, and transplantation.

Stem cells translational medicine - 1 Sept 2012

Van Zant Gary, Liang Ying

Abstract excerpt

Self-renewal and multilineage differentiation of stem cells are keys to the lifelong homeostatic maintenance of tissues and organs. Hematopoietic aging, characterized by immunosenescence, proinflammation, and anemia, is attributed to age-associated changes in the number and function of hematopoietic stem cells (HSCs) and their microenvironmental niche. Genetic variants and factors regulating stem cell aging are...

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Identifiers

PMID: 23197871
DOI: 10.5966/sctm.2012-0033
PMCID: PMC3659734

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