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Article

Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex

24 Mar 2011

Abstract excerpt

BACKGROUND: The β-amyloid precursor protein (APP) and the related β-amyloid precursor-like proteins (APLPs) undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer's disease, the physiological role of APP family members and their diverse proteolytic products is still largely unknown. The secreted APPsα...

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PMID: 21435241
DOI: 10.1186/1471-2164-12-160

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