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Article

CD39 dynamics in tuberculosis: a potential biomarker of immune dysregulation and T cell exhaustion

11 Aug 2025

Abstract excerpt

Background Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global health crisis complicated by immune dysregulation and T cell exhaustion. CD39, an ectonucleotidase generating immunosuppressive adenosine, is implicated in cancer and chronic infections, yet its spatiotemporal role in TB pathogenesis remains unclear. Methods Multiple publicly available datasets were utilized to evaluate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40861457
DOI: 10.3389/fimmu.2025.1601637

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