Article

Control of pancreatic islet function and glucose homeostasis by a novel microexon program misregulated in type 2 diabetes

2022-04-02

Abstract excerpt

Pancreatic islets control glucose homeostasis by the balanced secretion of insulin and other hormones, and their abnormal function causes diabetes or hypoglycemia. Here, we uncover a conserved program of alternative microexons included in mRNAs of islet cells, particularly in genes involved in vesicle transport and exocytosis. Islet microexons (IsletMICs) are regulated by the RNA binding protein SRRM3 and represe...

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Literature Corpus work: 9ac4f39b-b7f0-54fd-8a2f-24b6cb334ab7
DOI: 10.1101/2022.04.02.486809

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