Article

Metabolic Alterations in Human Peripheral Blood Mononuclear Cells Associate with Progression to Islet Autoimmunity and Type 1 Diabetes

2019-06-03

Abstract excerpt

<h4>ABSTRACT</h4> Previous metabolomics studies suggest that type 1 diabetes (T1D) is preceded by specific metabolic disturbances. Here we asked whether distinct metabolic patterns occur in peripheral blood mononuclear cells (PBMCs) of children later developing pancreatic β -cell autoimmunity or overt T1D. In a longitudinal cohort setting, PBMC metabolomic analysis was applied in children who either (1) progress...

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Literature Corpus work: 9abf2db6-88bf-5a2a-9a99-355a3c7fff93
DOI: 10.1101/658500

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