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Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study.

Diabetes - 1 Mar 2020

Li Qian, Parikh Hemang, Butterworth Martha D, Lernmark Åke, Hagopian William, Rewers Marian, She Jin-Xiong, Toppari Jorma, Ziegler Anette-G, Akolkar Beena, Fiehn Oliver, Fan Sili, Krischer Jeffrey P

Abstract excerpt

Children at increased genetic risk for type 1 diabetes (T1D) after environmental exposures may develop pancreatic islet autoantibodies (IA) at a very young age. Metabolic profile changes over time may imply responses to exposures and signal development of the first IA. Our present research in The Environmental Determinants of Diabetes in the Young (TEDDY) study aimed to identify metabolome-wide signals preceding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32029481
DOI: 10.2337/db19-0756
PMCID: PMC7034190

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Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study.PMID 32029481Read ↗

Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes: The TEDDY Study.Semantic proximity Read ↗

Prediction of the development of islet autoantibodies through integration of environmental, genetic, and metabolic markers.Semantic proximity Read ↗

Integrative analyses of TEDDY Omics data reveal lipid metabolism abnormalities, increased intracellular ROS and heightened inflammation prior to autoimmunity for type 1 diabetes.Semantic proximity Read ↗

Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes.Semantic proximity Read ↗

Metabolic Alterations in Human Peripheral Blood Mononuclear Cells Associate with Progression to Islet Autoimmunity and Type 1 DiabetesSemantic proximity Read ↗

Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease.Semantic proximity Read ↗

Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes.Semantic proximity Read ↗

Causes of early-onset type 1 diabetes: toward data-driven environmental approaches.Semantic proximity Read ↗

The Environmental Determinants of Diabetes in the Young (TEDDY) Study.Semantic proximity Read ↗

Integration of Infant Metabolite, Genetic, and Islet Autoimmunity Signatures to Predict Type 1 Diabetes by Age 6 Years.Semantic proximity Read ↗

Erythrocyte membrane docosapentaenoic acid levels are associated with islet autoimmunity: the Diabetes Autoimmunity Study in the Young.Semantic proximity Read ↗

Persistent alterations in plasma lipid profiles prior to introduction of gluten in the diet associate with progression to celiac diseaseSemantic proximity Read ↗

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