Article
Integrative analyses of TEDDY Omics data reveal lipid metabolism abnormalities, increased intracellular ROS and heightened inflammation prior to autoimmunity for type 1 diabetes.
Genome biology - 21 Jan 2021
Balzano-Nogueira Leandro, Ramirez Ricardo, Zamkovaya Tatyana, Dailey Jordan, Ardissone Alexandria N, Chamala Srikar, Serrano-Quílez Joan, Rubio Teresa, Haller Michael J, Concannon Patrick, Atkinson Mark A, Schatz Desmond A, Triplett Eric W, Conesa Ana
Abstract excerpt
BACKGROUND: The Environmental Determinants of Diabetes in the Young (TEDDY) is a prospective birth cohort designed to study type 1 diabetes (T1D) by following children with high genetic risk. An integrative multi-omics approach was used to evaluate islet autoimmunity etiology, identify disease biomarkers, and understand progression over time. RESULTS: We identify a multi-omics signature that was predictive of...
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