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Article

Metabolic alterations in immune cells associate with progression to type 1 diabetes.

Diabetologia - 1 May 2020

Sen Partho, Dickens Alex M, López-Bascón María Asunción, Lindeman Tuomas, Kemppainen Esko, Lamichhane Santosh, Rönkkö Tuukka, Ilonen Jorma, Toppari Jorma, Veijola Riitta, Hyöty Heikki, Hyötyläinen Tuulia, Knip Mikael, Orešič Matej

Abstract excerpt

AIMS/HYPOTHESIS: Previous metabolomics studies suggest that type 1 diabetes is preceded by specific metabolic disturbances. The aim of this study was to investigate whether distinct metabolic patterns occur in peripheral blood mononuclear cells (PBMCs) of children who later develop pancreatic beta cell autoimmunity or overt type 1 diabetes. METHODS: In a longitudinal cohort setting, PBMC metabolomic analysis was...

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Share to Autoantibodies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Islets of Langerhans

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Source

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Identifiers

PMID: 32043185
DOI: 10.1007/s00125-020-05107-6
PMCID: PMC7145788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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