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Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes: The TEDDY Study.

Diabetes - 1 Jan 2021

Li Qian, Liu Xiang, Yang Jimin, Erlund Iris, Lernmark Åke, Hagopian William, Rewers Marian, She Jin-Xiong, Toppari Jorma, Ziegler Anette-G, Akolkar Beena, Krischer Jeffrey P

Abstract excerpt

Children's plasma metabolome, especially lipidome, reflects gene regulation and dietary exposures, heralding the development of islet autoantibodies (IA) and type 1 diabetes (T1D). The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8,676 newborns by screening of HLA-DR-DQ genotypes at six clinical centers in four countries, profiled metabolome, and measured concentrations of ascorbic...

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Identifiers

PMID: 33106256
DOI: 10.2337/db20-0696
PMCID: PMC7876562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes: The TEDDY Study.PMID 33106256Read ↗

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