Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice

Abstract excerpt

Severe disease following infection with SARS-CoV or SARS-CoV-2 is driven in part by genetically regulated immune responses that promote lung injury. To study genetic mechanisms of immune-mediated coronavirus pathogenesis, we screened the Collaborative Cross (CC) panel for Mus musculus strains that are phenotypically divergent with respect to coronavirus susceptibility. We identified CC006/TauUnc and CC044/UncJ as...

Topics

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• interferon and immune responses
• SARS-CoV-2 and COVID-19 Research
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

9ab1c289-7f9e-5629-812b-afa746d4108a

DOI

10.17615/nr66-ck69