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Article

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.

PLoS genetics - 1 Oct 2015

Gralinski Lisa E, Ferris Martin T, Aylor David L, Whitmore Alan C, Green Richard, Frieman Matthew B, Deming Damon, Menachery Vineet D, Miller Darla R, Buus Ryan J, Bell Timothy A, Churchill Gary A, Threadgill David W, Katze Michael G, McMillan Leonard, Valdar William, Heise Mark T, Pardo-Manuel de Villena Fernando, Baric Ralph S

Abstract excerpt

New systems genetics approaches are needed to rapidly identify host genes and genetic networks that regulate complex disease outcomes. Using genetically diverse animals from incipient lines of the Collaborative Cross mouse panel, we demonstrate a greatly expanded range of phenotypes relative to classical mouse models of SARS-CoV infection including lung pathology, weight loss and viral titer. Genetic mapping...

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Source

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Identifiers

PMID: 26452100
DOI: 10.1371/journal.pgen.1005504
PMCID: PMC4599853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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