Cross-coronavirus host susceptibility loci influence disease severity through immune mediators

Abstract excerpt

Severe disease following infection with SARS-CoV or SARS-CoV-2 is driven in part by genetically regulated immune responses that promote lung injury. Previously, we showed that genetic risk for severe disease is conserved across viruses and between mouse and human, identifying the HrS43 locus as a shared determinant of severity. Here, to resolve immune pathways linking host loci to disease outcomes, we apply an in...

Topics

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• Chromosome Mapping
• COVID-19
• Disease Models, Animal
• Disease Susceptibility
• Mice
• Quantitative Trait Loci
• SARS-CoV-2
• Severe acute respiratory syndrome-related coronavirus

Identifiers and source

Literature Corpus work

28b5add0-0194-5832-9c4c-752780b8354f

DOI

10.64898/2026.03.23.713300