Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.

doi:10.1371/journal.ppat.1003196

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.

PLoS pathogens - 1 Feb 2013

Ferris Martin T, Aylor David L, Bottomly Daniel, Whitmore Alan C, Aicher Lauri D, Bell Timothy A, Bradel-Tretheway Birgit, Bryan Janine T, Buus Ryan J, Gralinski Lisa E, Haagmans Bart L, McMillan Leonard, Miller Darla R, Rosenzweig Elizabeth, Valdar William, Wang Jeremy, Churchill Gary A, Threadgill David W, McWeeney Shannon K, Katze Michael G, Pardo-Manuel de Villena Fernando, Baric Ralph S, Heise Mark T

Abstract excerpt

Genetic variation contributes to host responses and outcomes following infection by influenza A virus or other viral infections. Yet narrow windows of disease symptoms and confounding environmental factors have made it difficult to identify polymorphic genes that contribute to differential disease outcomes in human populations. Therefore, to control for these confounding environmental variables in a system that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Host-Pathogen Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A virus

Share to Influenza, Human

Share to Lung

Share to Mice, Inbred Strains

Share to Orthomyxoviridae Infections

Share to Reassortant Viruses

Share to Rodent Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 23468633
DOI: 10.1371/journal.ppat.1003196
PMCID: PMC3585141

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.PMID 23468633Read ↗

Expression Quantitative Trait Loci for Extreme Host Response to Influenza A in Pre-Collaborative Cross MiceSemantic proximity Read ↗

Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice.Semantic proximity Read ↗

Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative CrossSemantic proximity Read ↗

Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.Semantic proximity Read ↗

Genetic regulation of homeostatic immune architecture in the lungs of Collaborative Cross miceSemantic proximity Read ↗

The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases.Semantic proximity Read ↗

Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross.Semantic proximity Read ↗

Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross.Semantic proximity Read ↗

Adaptive immune response to West Nile virus infection in the Collaborative Cross mouse model: A database of cellular phenotypes and Quantitative Trait Loci.Semantic proximity Read ↗

Mapping of clinical and expression quantitative trait loci in a sex-dependent effect of host susceptibility to mouse-adapted influenza H3N2/HK/1/68.Semantic proximity Read ↗

Giving the Genes a Shuffle: Using Natural Variation to Understand Host Genetic Contributions to Viral Infections.Semantic proximity Read ↗

Host genetics of severe influenza: from mouse Mx1 to human IRF7Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.