Article
Sarbecovirus disease susceptibility is conserved across viral and host models.
Virus research - 1 Aug 2024
Leist Sarah R, Schäfer Alexandra, Risemberg Ellen L, Bell Timothy A, Hock Pablo, Zweigart Mark R, Linnertz Colton L, Miller Darla R, Shaw Ginger D, de Villena Fernando Pardo Manuel, Ferris Martin T, Valdar William, Baric Ralph S
Abstract excerpt
Coronaviruses have caused three severe epidemics since the start of the 21st century: SARS, MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing likelihood of future coronavirus outbreaks motivates greater understanding of factors leading to severe coronavirus disease. We screened ten strains from the Collaborative Cross mouse genetic reference panel and identified strains CC006/TauUnc...
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