Article
Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice.
PLoS pathogens - 1 Jan 2021
Graham Jessica B, Swarts Jessica L, Leist Sarah R, Schäfer Alexandra, Menachery Vineet D, Gralinski Lisa E, Jeng Sophia, Miller Darla R, Mooney Michael A, McWeeney Shannon K, Ferris Martin T, Pardo-Manuel de Villena Fernando, Heise Mark T, Baric Ralph S, Lund Jennifer M
Abstract excerpt
The COVID-19 pandemic has revealed that infection with SARS-CoV-2 can result in a wide range of clinical outcomes in humans. An incomplete understanding of immune correlates of protection represents a major barrier to the design of vaccines and therapeutic approaches to prevent infection or limit disease. This deficit is largely due to the lack of prospectively collected, pre-infection samples from individuals...
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