Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes

Abstract excerpt

<h4>ABSTRACT</h4> Transcriptional condensates anchored by chromatin readers are increasingly recognized as organizing hubs for gene expression, but how their assembly and stability are regulated remains poorly understood. Here, we identify an acetylation-dependent feed-forward circuit that controls the integrity of the Super Elongation Complex (SEC), a key driver of transcriptional elongation. We show that the SA...

Topics

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• Disease Management
• Gene Knockout Techniques
• Gene Rearrangement
• Histone Acetyltransferases
• Histone-Lysine N-Methyltransferase
• Myeloid Cells
• Myeloid-Lymphoid Leukemia Protein
• Oncogene Proteins, Fusion

Identifiers and source

Literature Corpus work

9a97c07e-6eb6-526e-baed-d1075163ee62

DOI

10.64898/2026.07.13.737885