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Article

KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.

Leukemia - 1 Apr 2021

Au Yan Zi, Gu Muxin, De Braekeleer Etienne, Gozdecka Malgorzata, Aspris Demetrios, Tarumoto Yusuke, Cooper Jonathan, Yu Jason, Ong Swee Hoe, Chen Xi, Tzelepis Konstantinos, Huntly Brian J P, Vassiliou George, Yusa Kosuke

Abstract excerpt

Histone acetyltransferases (HATs) catalyze the transfer of an acetyl group from acetyl-CoA to lysine residues of histones and play a central role in transcriptional regulation in diverse biological processes. Dysregulation of HAT activity can lead to human diseases including developmental disorders and cancer. Through genome-wide CRISPR-Cas9 screens, we identified several HATs of the MYST family as fitness genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32764680
DOI: 10.1038/s41375-020-1001-z
PMCID: PMC7610570

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