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Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression.

Cancer discovery - 2 Aug 2024

Liu Yiman, Li Qinglan, Song Lele, Gong Chujie, Tang Sylvia, Budinich Krista A, Vanderbeck Ashley, Mathias Kaeli M, Wertheim Gerald B, Nguyen Son C, Outen Riley, Joyce Eric F, Maillard Ivan, Wan Liling

Abstract excerpt

Gain-of-function mutations in the histone acetylation "reader" eleven-nineteen-leukemia (ENL), found in acute myeloid leukemia (AML) and Wilms tumor, are known to drive condensate formation and gene activation in cellular systems. However, their role in tumorigenesis remains unclear. Using a conditional knock-in mouse model, we show that mutant ENL perturbs normal hematopoiesis, induces aberrant expansion of...

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Identifiers

PMID: 38655899
DOI: 10.1158/2159-8290.CD-23-0876
PMCID: PMC11294821

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