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Article

Targeting the Menin-KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to Clinical Translation.

European journal of haematology - 1 Jul 2026

Bruzzese Antonella, Vigna Ernesto, Martino Enrica Antonia, Caserta Santino, Mendicino Francesco, Alvaro Maria Eugenia, Labanca Caterina, Lucia Eugenio, Olivito Virginia, Skafi Mamdouh, Amodio Nicola, Morabito Fortunato, Gentile Massimo

Abstract excerpt

Acute leukemias characterized by a shared epigenetic dependency on the menin-KMT2A axis rely on aberrant HOX-driven transcriptional programs that sustain leukemic self-renewal and impair differentiation. This dependency is most evident in KMT2A-rearranged and NPM1-mutated acute myeloid leukemia (AML), but also extends to other HOX-dependent entities, including leukemias with NUP98 rearrangements and UBTF tandem...

Read the complete abstract on PubMed

Topics

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Share to Epigenesis, Genetic
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Leukemia, Myeloid, Acute

Share to Molecular Targeted Therapy

Share to Myeloid-Lymphoid Leukemia Protein

Share to Nucleophosmin

Share to Translational Research, Biomedical

Source

Identifiers

PMID: 41923577
DOI: 10.1111/ejh.70186

Genes

KMT2A
FLT3
MEIS1
NPM1
NUP98

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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