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Article

Causal Relationships Between Plasma Metabolites, Inflammatory Factors, and Oral Cancer Risk: A Comprehensive Mendelian Randomization Study With Mediation Analysis.

Human mutation - 1 Jan 2026

Hu Shaonan, Liu Chufeng, Ren Minghua

Abstract excerpt

This study conducted a large-scale Mendelian randomization analysis using genome-wide single nucleotide polymorphisms (SNPs) as instrumental variables to investigate the causal relationships between 1400 circulating metabolites and oral cancer risk. The genetic data were derived from the Canadian Longitudinal Study on Aging (CLSA) cohort and the IEU OpenGWAS database. The study employed germline genetic variants...

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Aspartic Acid
Genome-Wide Association Study
Inflammation
Inflammation Mediators
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mouth Neoplasms

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PMID: 41660552
DOI: 10.1155/humu/4387817
PMCID: PMC12878797

Genes

CCL11
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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