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Article

Multivariable Mendelian randomization study supports the causal effects of circulating metabolites on frailty.

Aging clinical and experimental research - 13 Aug 2025

Yang Fan, Xue Mengjuan, Xu Han, Li Ouyang, Kim Dayoung, Lu Bin, Bao Zhijun

Abstract excerpt

Aging-related frailty increases the risk of falls, disability, and mortality. Frailty is linked to abnormalities in whole-body metabolism. However, the causal relationship between circulating metabolic traits and frailty remains unclear. This study aims to clarify the causal effects of circulating metabolites on frailty. We used bidirectional two sample and multivariable Mendelian Randomization (MVMR) methods to...

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Aging
Frailty
Genome-Wide Association Study
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40802156
DOI: 10.1007/s40520-025-03149-7
PMCID: PMC12350487

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