Article

Epigenetic Profiling for the Molecular Classification of Metastatic Brain Tumors

2018-02-22

Abstract excerpt

Optimal treatment of brain metastases is often hindered by limitations in diagnostic capabilities. To meet these challenges, we generated genome-scale DNA methylomes of the three most frequent types of brain metastases: melanoma, breast, and lung cancers (n=96). Using supervised machine learning and integration of multiple DNA methylomes from normal, primary, and metastatic tumor specimens (n=1,860), we unraveled...

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Literature Corpus work: 9a1cb8dc-4673-5dd6-976b-a2445e09b074
DOI: 10.1101/268193

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