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Article

Decoding molecular programs in melanoma brain metastases.

Nature communications - 26 Nov 2022

Radke Josefine, Schumann Elisa, Onken Julia, Koll Randi, Acker Güliz, Bodnar Bohdan, Senger Carolin, Tierling Sascha, Möbs Markus, Vajkoczy Peter, Vidal Anna, Högler Sandra, Kodajova Petra, Westphal Dana, Meier Friedegund, Heppner Frank, Kreuzer-Redmer Susanne, Grebien Florian, Jürchott Karsten, Redmer Torben

Abstract excerpt

Melanoma brain metastases (MBM) variably respond to therapeutic interventions; thus determining patient's prognosis. However, the mechanisms that govern therapy response are poorly understood. Here, we use a multi-OMICS approach and targeted sequencing (TargetSeq) to unravel the programs that potentially control the development of progressive intracranial disease. Molecularly, the expression of E-cadherin (Ecad)...

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Identifiers

PMID: 36435874
DOI: 10.1038/s41467-022-34899-x
PMCID: PMC9701224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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