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Prediction of brain metastasis development with DNA methylation signatures

8 Oct 2024

Abstract excerpt

Brain metastases (BMs) are the most common and among the deadliest brain tumors. Currently, there are no reliable predictors of BM development from primary cancer, which limits early intervention. Lung adenocarcinoma (LUAD) is the most common BM source and here we obtained 402 tumor and plasma samples from a large cohort of patients with LUAD with or without BM (n = 346). LUAD DNA methylation signatures were...

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PMID: 39379704
DOI: 10.1038/s41591-024-03286-y

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