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Article

DNA methylation and gene deletion analysis of brain metastases in melanoma patients identifies mutually exclusive molecular alterations.

Neuro-oncology - 1 Nov 2014

Marzese Diego M, Scolyer Richard A, Roqué Maria, Vargas-Roig Laura M, Huynh Jamie L, Wilmott James S, Murali Rajmohan, Buckland Michael E, Barkhoudarian Garni, Thompson John F, Morton Donald L, Kelly Daniel F, Hoon Dave S B

Abstract excerpt

BACKGROUND: The brain is a common target of metastases for melanoma patients. Little is known about the genetic and epigenetic alterations in melanoma brain metastases (MBMs). Unraveling these molecular alterations is a key step in understanding their aggressive nature and identifying novel therapeutic targets. METHODS: Genome-wide DNA methylation analyses of MBMs (n = 15) and normal brain tissues (n = 91) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24968695
DOI: 10.1093/neuonc/nou107
PMCID: PMC4201072

Genes

BRAF
CDH13
NRAS
APC
ESR1
PTEN
RARB
RASSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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