Article

KDM6 Enzymes are the Mechanistic Targets of Mutant IDH that Dictate Replication Stress Sensitivity

2026-04-17

Abstract excerpt

<h4>ABSTRACT</h4> Cancer-associated isocitrate dehydrogenase (IDH) mutations sensitize gliomas to replication stress, although the underlying mechanisms are unclear. IDH-mutant enzymes synthesize ( R )-2-hydroxyglutarate (R2HG), which broadly inhibits 2-oxoglutarate-dependent enzymes. We performed forward genetic screens targeting all 2-oxoglutarate-dependent enzymes and discovered that KDM6 histone demethylases...

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Literature Corpus work: 5fca3c0e-a442-5167-8318-4566874e8ea7
DOI: 10.64898/2026.04.14.715350

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