Article

Identifying Combinations of Cancer Drivers in Individual Patients

2019-06-19

Abstract excerpt

<h4>ABSTRACT</h4> Identifying the subset of genetic alterations present in individual tumors that are essential and collectively sufficient for cancer initiation and progression would advance the development of effective personalized treatments. We present CRSO for inferring the combinations of alterations, i.e., rules, that cooperate to drive tumor formation in individual patients. CRSO prioritizes rules by inte...

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Literature Corpus work: 99f4a62b-b5ba-5d1b-a71e-dc8812569e9c
DOI: 10.1101/674234

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