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Article

Identifying modules of cooperating cancer drivers.

Molecular systems biology - 1 Mar 2021

Klein Michael I, Cannataro Vincent L, Townsend Jeffrey P, Newman Scott, Stern David F, Zhao Hongyu

Abstract excerpt

Identifying cooperating modules of driver alterations can provide insights into cancer etiology and advance the development of effective personalized treatments. We present Cancer Rule Set Optimization (CRSO) for inferring the combinations of alterations that cooperate to drive tumor formation in individual patients. Application to 19 TCGA cancer types revealed a mean of 11 core driver combinations per cancer,...

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Identifiers

PMID: 33769711
DOI: 10.15252/msb.20209810
PMCID: PMC7995435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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