Article

Identifying Modules of Cooperating Cancer Drivers

2020-06-29

Abstract excerpt

<h4> A bstract </h4> Identifying cooperating modules of driver alterations can provide biological insights to cancer causation and would advance the development of effective personalized treatments. We present Cancer Rule-Set Optimization (CRSO) for inferring the combinations of alterations that cooperate to drive tumor formation in individual patients. Application to 19 TCGA cancer types found a mean of 11 cor...

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Literature Corpus work: 8ed58bf9-9194-5eae-8654-1a06078f214c
DOI: 10.1101/2020.06.29.168229

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