Article

The Gene Pax4 Is an Essential Regulator of Pancreatic β-Cell Development

2004-12-01

Abstract excerpt

The Pax-gene family encodes a group of transcription factors characterized by the presence of a highly conserved DNA-binding motif, the paired domain. Pax proteins are key regulators of vertebrate organogenesis since they play major roles in embryonic pattern formation, cell proliferation and cell differentiation (Chi and Epstein, 2002; Dahl et al., 1997; Dohrman et al., 2000; Epstein et al., 1994). Indeed, mutati...

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Literature Corpus work: 99e1cf2f-9642-5c01-b64a-282e733d54f0
DOI: 10.1016/s1016-8478(23)13114-1

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