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Article

The Diabetes-Linked Transcription Factor PAX4: From Gene to Functional Consequences

9 Mar 2017

Abstract excerpt

Paired box 4 (PAX4) is a key factor in the generation of insulin producing β-cells during embryonic development. In adult islets, PAX4 expression is sequestered to a subset of β-cells that are prone to proliferation and more resistant to stress-induced apoptosis. The importance of this transcription factor for adequate pancreatic islets functionality has been manifested by the association of mutations in PAX4...

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PMID: 28282933
DOI: 10.3390/genes8030101

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