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Pax4 in Health and Diabetes

5 May 2023

Abstract excerpt

Paired box 4 (Pax4) is a key transcription factor involved in the embryonic development of the pancreatic islets of Langerhans. Consisting of a conserved paired box domain and a homeodomain, this transcription factor plays an essential role in early endocrine progenitor cells, where it is necessary for cell-fate commitment towards the insulin-secreting β cell lineage. Knockout of Pax4 in animal models leads to...

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PMID: 37175989
DOI: 10.3390/ijms24098283

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PAX6 maintains β cell identity by repressing genes of alternative islet cell typesSemantic proximity Read ↗

PAX4 loss of function alters human endocrine cell development and influences diabetes riskSemantic proximity Read ↗

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PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic IsletSemantic proximity Read ↗

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