Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Transcription Factor PAX4: Role in Differentiation of Insulin- Producing β Cells during Pancreas Development and Association with Diabetes].

Molekuliarnaia biologiia - 1 Jan 2025

Melnikova A I, Krasnova T S, Rubtsov P M

Abstract excerpt

PAX4 (Paired Box 4) is a transcription factor that is expressed mainly in the pancreas and plays a key role in the development of insulin-producing β cells at the embryonic stage. In mature cells, PAX4 acts as a main regulator of their adaptation under pathological conditions. The importance of PAX4 to the proper function of pancreatic islets has been demonstrated in studies of the relationship between mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Diabetes Mellitus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Homeodomain Proteins

Share to Insulin

Share to Insulin-Secreting Cells

Share to Paired Box Transcription Factors

Share to Pancreas

Source

Identifiers

PMID: 40558032
DOI: 10.31857/S0026898425020023

Genes

PAX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Transcription Factor PAX4: Role in Differentiation of Insulin- Producing β Cells during Pancreas Development and Association with Diabetes].PMID 40558032Read ↗

Pax4 in Health and DiabetesSemantic proximity Read ↗

Therapeutic potential of pancreatic PAX4-regulated pathways in treating diabetes mellitus.Semantic proximity Read ↗

A focus on the role of Pax4 in mature pancreatic islet β-cell expansion and survival in health and diseaseSemantic proximity Read ↗

The Diabetes-Linked Transcription Factor PAX4: From Gene to Functional ConsequencesSemantic proximity Read ↗

The Gene Pax4 Is an Essential Regulator of Pancreatic β-Cell DevelopmentSemantic proximity Read ↗

The gene Pax4 is an essential regulator of pancreatic beta-cell development.Semantic proximity Read ↗

PDX1 is the cornerstone of pancreatic β-cell functions and identitySemantic proximity Read ↗

The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1Semantic proximity Read ↗

PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic IsletSemantic proximity Read ↗

PAX4 Gene Transfer Induces α-to-β Cell Phenotypic Conversion and Confers Therapeutic Benefits for Diabetes TreatmentSemantic proximity Read ↗

PAX6 maintains β cell identity by repressing genes of alternative islet cell typesSemantic proximity Read ↗

Crucial Role of PDX-1 in Pancreas Development, β-Cell Differentiation, and Induction of Surrogate β-CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.