Article
The gene Pax4 is an essential regulator of pancreatic beta-cell development.
Molecules and cells - 31 Dec 2004
Sosa-Pineda Beatriz
Abstract excerpt
The Pax-gene family encodes a group of transcription factors characterized by the presence of a highly conserved DNA-binding motif, the paired domain. Pax proteins are key regulators of vertebrate organogenesis since they play major roles in embryonic pattern formation, cell proliferation and cell differentiation (Chi and Epstein, 2002; Dahl et al., 1997; Dohrman et al., 2000; Epstein et al., 1994). Indeed,...
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