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Article

Profiling the TRPV4 ankyrin repeat domain interactome and its disruption by neuromuscular disease-causing mutations.

The Journal of biological chemistry - 1 Jan 2026

Loder Alexis K, Kosmanopoulos Gage P, Aisenberg William H, Cox Eric, Meeker Alexis R, Blackshaw Seth, Gaudet Rachelle, Hellmich Ute A, McCray Brett A, Sumner Charlotte J, Sullivan Jeremy M

Abstract excerpt

The ankyrin repeat is one of the most abundant protein-protein interaction motifs in eukaryotes yet occurs in only a small number of ion channels. These channels are all members of the transient receptor potential (TRP) superfamily and contain prominent ankyrin repeat domains (ARDs) in their cytoplasmic N termini. In transient receptor potential vanilloid 4 (TRPV4), the importance of this domain has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41338459
DOI: 10.1016/j.jbc.2025.110991
PMCID: PMC12796746

Genes

TRPV4
ARHGEF10
NEDD4L
OTUB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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